Open the box, unpack stuff, got upset that the power supply has a new MagSafe adapter - this means my old power brick will not serve without an adapter.
Charge the battery. Set up the basics and register the Mac.
Log in for the first time. Change the background, make the dock smaller.
Set the trackpad to the tap mode - I prefer light tapping to strong clicking.
Remove some apps from the dock that I rarely use: the stock email reader, FaceTime, Contacts, etc. Many of these are integrated in Google apps.

Tweaks

Fix Safari (and Chrome) settings to not save passwords, and start with my favorite start page.
Move Terminal shortcut to the Dock
Terminal->Properties->Settings->Shell-> change "When the shell exits" to "Close if the shell exited cleanly"
Terminal->Properties->Window change width to 120 - I wan to see long messages.
System Preferences -> Languages and Text; also in Keyboard, and add and enable options for Latvian text input support.

AppStore

Install some apps from the AppStore:

Install some apps from other sources, or directly from the developer.

There are some things that I have decided to stay away based on previous experiences or storage and other restrictions.